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Configuration

TrialDesignBench reads configuration from the selected workspace .env file. The CLI creates this file with safe defaults and gitignores it inside the workspace.

Variable Required Purpose
MATHPIX_APP_ID Yes Mathpix API application ID.
MATHPIX_APP_KEY Yes Mathpix API key.
CODEX_MODEL No Local Codex model name. Defaults to gpt-5.5.
CODEX_BIN No Path to a specific local codex binary.

The Mathpix credentials are sent as app_id and app_key headers for PDF upload, status polling, and result download. PDF processing is asynchronous: TrialDesignBench uploads the file, polls until completion, then downloads the .mmd result and optional .tex.zip conversion.

The Codex SDK integration uses the GitHub-hosted openai-codex Python package declared in pyproject.toml for uv environments. The default reproduction run uses model_reasoning_effort="high" when starting the Codex thread and effort="high" for the turn run.

The Git source declaration makes uv sync sufficient from a TrialDesignBench checkout. PyPI package metadata cannot rely on uv source tables, so PyPI-only consumers may need to add the same SDK Git source explicitly until openai-codex is available from a package index.

The current Python SDK schema does not expose toggle_fast_mode or an equivalent fast-mode setting, so TrialDesignBench does not send that option.